Systemic side effects of Corticosteroids

What is the systemic side effects of steroids ?:

   Weight gain, changes in mood, sleeplessness, increased appetite, high blood pressure, osteoporosis, muscle weakness, and an increased risk of infection are just a few of the systemic side effects of corticosteroids can cause. Prolonged use can also result in the suppression of the adrenal glands, a higher risk of certain infections, and eye disorders like glaucoma and cataracts. If your doctor has prescribed corticosteroids, you should talk to them about these problems.

   Due to these serious systemic side effects of Corticosteroids it is necessary to know about side effects deeply:

   ● Increase blood sugar levels: 

It is true that corticosteroids may affect blood sugar levels. By increasing gluconeogenesis or the production of glucose from non-carbohydrate sources, and reducing cell uptake of glucose, they can increase blood sugar levels. Those who have diabetes or are vulnerable to having high blood sugar levels are going to suffer this effect more severely. When using corticosteroids, it's necessary to regularly monitor your blood sugar levels and consult with your doctor to ensure proper treatment.

   ● Bone loss and bone death: 

As corticosteroids affect bone density and blood supply to bones, they can quite possibly cause bone loss and even osteonecrosis or death of the bone. Corticosteroids can weaken bones and increase the risk of fractures when used long-term or at high doses. They can also reduce blood supply to the bones, which can lead to osteonecrosis especially in the joints. It's important for people taking corticosteroids to infrom their doctor about any possible side effects and to think about techniques to prevent bone loss, like taking calcium and vitamin D supplements, doing regular weight-bearing exercise, or even taking medicine to maintain bone density.

   ● Weight gain: 

The common side effect of corticosteroids is weight gain. They can contribute to weight gain, particularly around the face, abdomen and back of the neck by increasing appetite and causing fluid retention. It's important to monitor your weight and consult a physician if you have any problems. They might recommend other drugs or dietary changes.

   ● High blood pressure: 

Actually, some people's blood pressure may increase while taking corticosteroids. They can result in potassium loss and sodium retention, which can increase blood pressure by causing fluid retention and an increase in blood volume. People using corticosteroids must routinely check their blood pressure and contact their physician if there are any changes or problems. Effective blood pressure management can require a change in lifestyle along with a medicine changes.

   ● Cataract and Glaucoma: 

High doses or long-term use of corticosteroids can increase the risk of glaucoma and cataracts. Clouding of the lens of the eye causes cataracts, while increased intraocular pressure damages the optic nerve in glaucoma. Regular eye examinations are necessary for corticosteroid patients in order to monitor for these potential side effects.

   ● Mood changes: 

It is true that corticosteroids have an impact on mood; in fact, they often result in irritability, anxiety, changes in mood and depression in some people. Depending on the dosage, duration of use and individual susceptibility, these effects might be different. When taking corticosteroids, it's important to inform your physician when observe your mood changes. There might be require changes in treatment plan.

   ● Infections: 

Corticosteroids will sometimes suppress the immune system, making a person more susceptible to infections especially if they are used regularly or in a high dose. It is possible for infections to develop including bacterial, fungal and even reactivate inactive diseases (e.g., tuberculosis). To reduce these risks, it's important to use corticosteroids carefully and under supervision by a physician.

   ● Skin changes: 

Stretch marks, acne, facial hair growth, thinning of the skin and easy bruising are only some of the skin problems that corticosteroids can produce. In addition, prolonged use may result in skin infections and delayed wound healing. It's important to take them according to prescribed and keep monitoring for any side effects.

Methylprednisolone: Introduction, Uses, Mode of action, Side effects, Doses and Available forms

Introduction:

   Methylprednisolone is one of corticosteroids medicines which mimic the functions of adrenal gland hormone. It is used to treat various conditions such as arthritis, asthma, allergie, inflammation, autoimmune disorders. It works by the suppressing immune system's response to inflammation.

Uses:

  Methylprednisolone is corticosteroids medicines used in various conditions like a inflammation, allerges, arthritis, asthma,skin diseases like a eczema and ringworm, and to suppress the immune response of body in autoimmune disorders like lupus and multiple sclerosis. It is also used in sudden severe allergic reactions of certain drugs ,foods or a other allergens. Never take a Methylprednisolone without suggestions of physician and follow his advice.

If you want to know Methylprednisolone uses In Tamil then click on this.

Other Corticosteroids:

● Prednisolone 

● Dexamethasone 

● Betamethasone 

Mode of action:

   Methylprednisolone is act by suppressing processes of inflammation and immune system response in body. It prevent the production of adrenal gland hormones and substances which require for a immune response and inflammation process, ultimately decrease the symptoms like allergy, swelling, pain and inflammation.

Side effects:

   Like a other corticosteroids Methylprednisolone can have a various side effects. If Methylprednisolone taken for long time can have a serious side effects. Some common side effects of Methylprednisolone is an increase appetite, weight gain, insomnia, mood changes, fluid retention, high blood pressure, increase risk of infections, stomach irritation and change in skin appearance. It is important to use Methylprednisolone only after an advice of physician and discuss any side effect if seen.

Dose:

   Dose of Methylprednisolone is depend on a condition of disease and nature and build of patient. An usually doses of Methylprednisolone can range from as low as 4mg to as high as 48mg. But again Methylprednisolone taken only after a physician advice.

Available Forms:

   Methylprednisolone is available in forms such as a tablets, injections and topicals cream or solution. Specific form being prescribed according to conditions of illness. Follow the route of administration of medications that suggest by a physician.

   

Betamethasone cream: Introduction, Uses, How to use, Side effect

Introduction:

Betamethasone valerate cream is topical corticosteroid. It is highly potent steroid that use to inhibits the release of substances in the body that cause inflammation Betamethasone cream used to treat inflammation and itching used by a number of skin disease like as eczema and psoriasis.

Uses:

Betamethasone cream is used to treat a variety of skin disorders, including dermatitis, psoriasis, and eczema. It functions by decreasing redness, swelling, and itching. It is also used in fungal infections with a anti fungal cream.

How to use?:

   Hand wash: 

To maintain hygiene, wash your hands well with soap and water before using the cream.

   Clean those affected area: 

Use a moderate soap and water solution to gently wash the affected region of skin, then wipe it dry.

   Apply a thin coating:

Using your fingers, squeeze a tiny bit of betamethasone cream and apply it in a thin layer to the affected area. Till it is completely absorbed into the skin, gently and evenly rub it in.

   Repeatedly wash your hands: 

After using the cream will help prevent unintentionally spreading the drug to other parts of your body.

   Frequency of application: 

Follow the instructions provided by your healthcare provider regarding the frequency of application. Typically, betamethasone cream is applied once or twice daily, but this may vary depending on the severity of your condition and your healthcare provider's recommendations.

   Avoid bandages or tight clothing: 

Unless directed otherwise by your healthcare provider, avoid covering the treated area with bandages or tight clothing, as this can increase the absorption of the medication into the skin.

   Avoid contact with eyes, mouth, and mucous membranes:

Be careful to avoid getting the cream in your eyes, mouth, or mucous membranes. If accidental contact occurs, rinse the area thoroughly with water.

   Use for the prescribed duration:

Use betamethasone cream for the duration prescribed by your healthcare provider, even if your symptoms improve before then. Stopping treatment prematurely can lead to a recurrence of symptoms.

Monitor for side effects:

Keep an eye out for any signs of irritation or allergic reaction, such as itching, redness, or swelling, and consult your healthcare provider if you experience any adverse effects.

   Application frequency:

Follow concentrate on the guidance your healthcare provider gives you on how often to apply. Applying betamethasone cream once or twice a day is the recommended method; however, this can change based on the severity of your disease and the advice of your healthcare professional.

   Avoid putting tight clothes or bandages:

Bandages or tight clothing should not be covered over the treated area unless your healthcare practitioner instructs you otherwise, as this may enhance the medication's absorption into the skin.

   Use for the advised length of duration:

Even if your symptoms subside before then, apply betamethasone cream for the duration of time that your doctor has suggested. An early stopping of treatment may cause symptoms to occur again.

   Keep watch for these possible adverse effects:

Watch for symptoms of irritation or allergic reaction, such as redness, swelling, or itching, and inform your doctor if you notice any adverse reactions.

Side effects:

Similar to other corticosteroids, betamethasone cream may have side effects that include burning, itching, thinning of the skin, and redness at the application site. Excessive or prolonged application may make these hazards worse. It is recommended that you use it according with medical advice and avoid from applying it to large regions of skin or for prolonged periods of time without a doctor's supervision.

Tablet Dexamethasone: Introduction, Definition, Mode of action, Uses, COVID-19 and Dexamethasone, Doses, Side effects

 Introduction:

   Dexamethasone is a member of the glucocorticoid class of drugs like a Prednisolone , which have a profound effect on inflammation, metabolism, immunological response, and stress management in the body. Because of its capacity to change these basic processes, it is an important instrument in the treatment of a wide range of diseases, from autoimmune diseases and some forms of cancer to inflammatory disorders and allergic reactions.

   Furthermore, recent events have brought dexamethasone to the spotlight as an essential ingredient in fighting against the COVID-19 pandemic, highlighting the importance of understanding its function in critical care conditions.

Definition:

   Dexamethasone is a synthetic corticosteroid medication with potent anti-inflammatory and immunosuppressive properties. It is a member of the glucocorticoid class of medications, which simulate the actions of corticosteroids that are naturally produced by the adrenal glands.

Mode of action:

   It works by suppressing the immune system and reducing inflammation by blocking the production of inflammatory substances in the body.

Uses:

   Dexamethasone's powerful anti-inflammatory and immunosuppressive qualities allow it a wide range of therapeutic applications. Among its frequent applications are:

   ● Inflammatory diseases: 

Rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Conjunctivitis and dermatitis are just some of the inflammatory illnesses that dexamethasone is used to treat.

   ● Allergic reactions: 

It is given to treat allergic dermatitis, allergic conjunctivitis, allergic asthma, and allergic rhinitis, among other allergic reactions' symptoms.

   ● Autoimmune diseases:

Rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus are among the autoimmune disorders for which dexamethasone is frequently a part of the treatments plan.

   ● Respiratory conditions:

 It can be used to manage respiratory conditions such as asthma exacerbations, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS). 

   ● Skin Disorders: 

To treat skin conditions such eczema, psoriasis, and allergic reactions, dexamethasone is used topically or included into formulations such as creams and ointments.

   ● Cancer:

Dexamethasone is used in cancer treatment to decrease inflammation, control chemotherapeutic side effects, and reduce symptoms of specific cancer types, like brain tumours and lymphomas.

   ● Nausea and Vomiting:

In some cases, doctors will prescribe it to cancer patients to stop chemotherapy-induced nausea and vomiting.

   ● Brain Edoema: 

Brain tumours and head injuries are common causes of cerebral edoema, which is treated with dexamethasone to lessen swelling.

   ● Organ Transplantation:

To keep organ transplant recipients from rejecting their new organs, immunosuppressive medication is administered in conjunction with dexamethasone. 

   ● COVID-19: 

Dexamethasone come to light during the pandemic due to its effectiveness in treating severe cases of the disease. Research has shown that administering this medication to hospitalised patients who need mechanical ventilation or more oxygen can lower their mortality rates.

These are just a few of the numerous applications for dexamethasone, indicating its range of uses and significance in modern medicine. However, because of its possible side effects and interactions with other drugs, dexamethasone must be used under a doctor's supervision.

COVID-19 and Dexamethasone:

The use of dexamethasone in the treatment of COVID-19 garnered significant attention during the pandemic, particularly in severe cases requiring hospitalization. Here's an overview:

   ● Clinical Trials:

Dexamethasone's efficacy in treating COVID-19 was demonstrated in the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial conducted in the United Kingdom. This large-scale trial found that dexamethasone reduced mortality rates in hospitalized COVID-19 patients who required supplemental oxygen or mechanical ventilation.

   ● Mechanism of Action:

Dexamethasone is thought to mitigate the severe inflammatory response associated with COVID-19, known as the cytokine storm. By suppressing the immune system's overactive response, dexamethasone helps reduce inflammation in the lungs and other organs, potentially preventing further damage.

   ● Treatment Protocol: 

Based on the findings of the RECOVERY trial and subsequent studies, dexamethasone has been incorporated into treatment protocols for severe COVID-19 cases in many healthcare settings worldwide. It is typically administered orally or intravenously at specific dosages for a specified duration under medical supervision.

   ● Patient Selection: 

Dexamethasone is primarily recommended for hospitalized COVID-19 patients who require supplemental oxygen therapy or mechanical ventilation. It may not be suitable for all patients, and its use should be guided by healthcare professionals based on individual patient characteristics and clinical status.

   ● Considerations and Monitoring: 

While dexamethasone has demonstrated benefits in reducing mortality rates in severe COVID-19 cases, it is not without potential risks and side effects. Patients receiving dexamethasone therapy require close monitoring for adverse reactions such as hyperglycemia, immunosuppression, secondary infections, and other complications associated with corticosteroid use.

   ● Ongoing Research: 

Research into the optimal timing, dosage, and duration of dexamethasone therapy for COVID-19 is ongoing, as scientists continue to refine treatment strategies and investigate potential combination therapies.

Overall, dexamethasone represents a valuable tool in the management of severe COVID-19 cases, offering hope for improved outcomes and reduced mortality rates. However, its use should be carefully considered and monitored within the context of comprehensive COVID-19 treatment protocols.

Side effects:

Increased hunger, weight gain, fluid retention, and mood swings are common side effects. Osteoporosis, elevated blood pressure, and increased susceptibility to infections are examples of more severe adverse effects. Prolonged usage may also decrease the body's normal hormone synthesis. It's important to go discuss risks and possible side effects with your doctor before starting any drug.